Methylmalonic Acid (MMA)
Methylmalonic acid (MMA) is a substance produced in small amounts during metabolism. Elevated levels are a sensitive and specific marker of vitamin B12 deficiency at the tissue level.
Category: Vitamins & Minerals
Also known as: methylmalonic acid, mma, serum mma, methylmalonate, metilmalonska kiselina
Reference range: 0–378 nmol/L (Source: ABIM)
Standard unit: nmol/L
High values may indicate
High MMA levels strongly suggest vitamin B12 deficiency, even when serum B12 levels appear normal. Elevated MMA may also occur in kidney disease or rare inherited metabolic disorders (methylmalonic acidemia).
Low values may indicate
Low or normal MMA levels indicate adequate vitamin B12 status at the cellular level.
Frequently asked questions
- What is a normal Methylmalonic Acid (MMA) level?
- A typical reference range for Methylmalonic Acid (MMA) is 0–378 nmol/L (source: ABIM). Reference ranges vary by laboratory, age, and sex, so always compare against the range on your own lab report.
- What units is Methylmalonic Acid (MMA) measured in?
- Methylmalonic Acid (MMA) is most commonly reported in nmol/L. Labs in different countries may use other units — you can convert between them with BloodId's blood test unit converter.
- Where do Methylmalonic Acid (MMA) reference ranges come from?
- BloodId uses ABIM standard reference ranges and educational information from MedlinePlus (see our methodology). Reference ranges still vary by lab, age, and sex, so always compare against your own report.
- Can I track Methylmalonic Acid (MMA) over time?
- Yes. Upload results from any lab and BloodId charts your Methylmalonic Acid (MMA) over time against its reference range, so you can see whether the trend is rising, falling, or stable.
Related biomarkers
Source: MedlinePlus, U.S. National Library of Medicine
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