Active Vitamin B12 (holotranscobalamin) measures the biologically available form of vitamin B12 that can be taken up by cells. It is considered a more accurate early marker of B12 deficiency than tot…
Category: Vitamins & Minerals
Also known as: active vitamin b12, active b12, holotranscobalamin, holotc, aktivni vitamin b12, holo-tc
Reference range: 25.1–165 pmol/L (Source: ABIM)
Standard unit: pmol/L
High values may indicate
High active B12 levels are generally not clinically significant and may reflect adequate or excessive B12 intake or supplementation.
Low values may indicate
Low active B12 levels indicate early vitamin B12 deficiency, even before total B12 levels drop, and may lead to megaloblastic anemia or neurological damage if untreated.