CH50 (total hemolytic complement) measures the overall functional activity of the entire classical complement pathway. It evaluates whether all complement proteins (C1 through C9) are working properl…
Category: Inflammation & Immune
Also known as: ch50, total complement, complement total, total hemolytic complement, ch 50
Reference range: 30–75 U/mL (Source: ABIM)
Standard unit: U/mL
High values may indicate
High CH50 levels may indicate acute inflammation, infection, or certain cancers, as complement proteins can increase during acute phase responses.
Low values may indicate
Low CH50 levels may indicate complement deficiency (inherited or acquired), active autoimmune diseases (especially lupus), immune complex diseases, or severe liver disease that impairs complement production.