Anti-dsDNA (anti-double-stranded DNA) antibodies are autoantibodies that target the body's own DNA. They are highly specific for systemic lupus erythematosus (SLE).
Category: Inflammation & Immune
Also known as: anti-dsdna, anti dsdna, double stranded dna antibody, anti-double stranded dna, dsdna antibody, ds-dna antibody
Reference range: 0–30 IU/mL (Source: ABIM)
Standard unit: IU/mL
High values may indicate
High anti-dsDNA levels strongly suggest systemic lupus erythematosus (SLE). Rising levels often correlate with lupus disease activity, particularly lupus nephritis (kidney involvement).
Low values may indicate
Low or negative anti-dsDNA levels make lupus less likely but do not entirely rule it out. Levels may decrease during periods of disease remission.