SHBG
SHBG (sex hormone-binding globulin) is a protein produced by the liver that binds to sex hormones (testosterone, estradiol, DHT) and controls how much is available for your body to use.
Category: Hormones
Also known as: shbg, sex hormone binding globulin, sex hormone-binding globulin, Androgen binding protein, Estradiol binding globulin, Sex steroid binding globulin, Sex steroid binding protein, Testosterone binding globulin
Reference range: 10–57 nmol/L (Source: ABIM)
Standard unit: nmol/L
High values may indicate
High SHBG levels may indicate hyperthyroidism, liver disease, anorexia nervosa, estrogen excess, or aging, and can reduce the amount of free (active) testosterone available.
Low values may indicate
Low SHBG levels may indicate obesity, type 2 diabetes, hypothyroidism, polycystic ovary syndrome (PCOS), or androgen excess, and can increase the amount of free testosterone.
Frequently asked questions
- What is a normal SHBG level?
- A typical reference range for SHBG is 10–57 nmol/L (source: ABIM). Reference ranges vary by laboratory, age, and sex, so always compare against the range on your own lab report.
- What units is SHBG measured in?
- SHBG is most commonly reported in nmol/L. Labs in different countries may use other units — you can convert between them with BloodId's blood test unit converter.
- Where do SHBG reference ranges come from?
- BloodId uses ABIM standard reference ranges and educational information from MedlinePlus (see our methodology). Reference ranges still vary by lab, age, and sex, so always compare against your own report.
- Can I track SHBG over time?
- Yes. Upload results from any lab and BloodId charts your SHBG over time against its reference range, so you can see whether the trend is rising, falling, or stable.