Pregnenolone
Pregnenolone is a steroid hormone produced from cholesterol and serves as the precursor to all other steroid hormones including cortisol, DHEA, progesterone, testosterone, and estrogen.
Category: Hormones
Also known as: pregnenolone, p5, serum pregnenolone, pregnenolon
Reference range: 10–200 ng/dL (Source: ABIM)
Standard unit: ng/dL
High values may indicate
High pregnenolone levels may indicate congenital adrenal hyperplasia (specific enzyme deficiencies), adrenal tumors, or supplementation. Elevated levels are uncommon in routine testing.
Low values may indicate
Low pregnenolone levels may indicate adrenal insufficiency, aging-related decline, chronic stress, or cholesterol metabolism disorders, and may contribute to fatigue and hormonal imbalances.
Frequently asked questions
- What is a normal Pregnenolone level?
- A typical reference range for Pregnenolone is 10–200 ng/dL (source: ABIM). Reference ranges vary by laboratory, age, and sex, so always compare against the range on your own lab report.
- What units is Pregnenolone measured in?
- Pregnenolone is most commonly reported in ng/dL. Labs in different countries may use other units — you can convert between them with BloodId's blood test unit converter.
- Where do Pregnenolone reference ranges come from?
- BloodId uses ABIM standard reference ranges and educational information from MedlinePlus (see our methodology). Reference ranges still vary by lab, age, and sex, so always compare against your own report.
- Can I track Pregnenolone over time?
- Yes. Upload results from any lab and BloodId charts your Pregnenolone over time against its reference range, so you can see whether the trend is rising, falling, or stable.
Related biomarkers
Source: MedlinePlus, U.S. National Library of Medicine
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