HE4
HE4 (Human Epididymis Protein 4) is a protein that is overexpressed by some ovarian cancer cells. This test is used alongside CA-125 to help evaluate pelvic masses and monitor ovarian cancer.
Category: Tumor Markers
Also known as: he4, he-4, human epididymis protein 4, human epididymis secretory protein 4
Reference range: 0–140 pmol/L (Source: ABIM)
Standard unit: pmol/L
High values may indicate
High HE4 levels may indicate epithelial ovarian cancer, endometrial cancer, or non-cancerous conditions such as renal failure or pulmonary fibrosis.
Low values may indicate
Low HE4 levels are normal and suggest a lower likelihood of epithelial ovarian cancer.
Frequently asked questions
- What is a normal HE4 level?
- A typical reference range for HE4 is 0–140 pmol/L (source: ABIM). Reference ranges vary by laboratory, age, and sex, so always compare against the range on your own lab report.
- What units is HE4 measured in?
- HE4 is most commonly reported in pmol/L. Labs in different countries may use other units — you can convert between them with BloodId's blood test unit converter.
- Where do HE4 reference ranges come from?
- BloodId uses ABIM standard reference ranges and educational information from MedlinePlus (see our methodology). Reference ranges still vary by lab, age, and sex, so always compare against your own report.
- Can I track HE4 over time?
- Yes. Upload results from any lab and BloodId charts your HE4 over time against its reference range, so you can see whether the trend is rising, falling, or stable.