HE4

HE4 (Human Epididymis Protein 4) is a protein that is overexpressed by some ovarian cancer cells. This test is used alongside CA-125 to help evaluate pelvic masses and monitor ovarian cancer.

Category: Tumor Markers

Also known as: he4, he-4, human epididymis protein 4, human epididymis secretory protein 4

Reference range: 0–140 pmol/L (Source: ABIM)

Standard unit: pmol/L

High values may indicate

High HE4 levels may indicate epithelial ovarian cancer, endometrial cancer, or non-cancerous conditions such as renal failure or pulmonary fibrosis.

Low values may indicate

Low HE4 levels are normal and suggest a lower likelihood of epithelial ovarian cancer.

Source: MedlinePlus, U.S. National Library of Medicine

Track your HE4 over time with BloodId